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The Machine tool spindle is most sophisticated member in machine tool and plays a vital role for better performance, higher efficiency and accuracy. Design of spindle is very important and a critical activity of machine tool design process. Spindles are integral part of the machine tool and responsible for quality of the final product produced and overall productivity of the machine tools. It is very essential analyze and optimize the design for low cost and better performance. Sizing of the spindle for machine capability in terms of dimension, power, speed, force and accuracy are the key challenges for machine designers for right machine and right application. Understanding the spindle design process is the first step for overall machine success.